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Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo (75)

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Kim YC, Shin MD, Hackett SF, Hsueh HT, Lima ESR, Date A, Han H, Kim BJ, Xiao A, Kim Y, Ogunnaike L, Anders NM, Hemingway A, He P, Jun AS, McDonnell PJ, Eberhart C, Pitha I, Zack DJ, Campochiaro PA, Hanes J, Ensign LM

It is suggested that astrocytes, tanycytes and the outer basement membrane function as a second barrier around these organs to prevent solutes to reach the rest of the brain [188]